Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors

Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors

Language: English

Pages: 392

ISBN: 0124170420

Format: PDF / Kindle (mobi) / ePub


Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance.

The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals.

  • Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement
  • Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic
  • Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations
  • Topics are discussed in terms of both human and animal studies

Dreamland: Adventures in the Strange Science of Sleep

Genetics: Analysis & Principles

Invisible: The Dangerous Allure of the Unseen

The God Particle

The Foundations of Acoustics: Basic Mathematics and Basic Acoustics

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA Roi Cohen Kadosh,     Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom Jonathan E. Draffin,     Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid, Madrid, Spain Martin Dresler Max Planck Institute of Psychiatry, Munich, Germany Donders Institute for Brain, Cognition and Behaviour, Radboud

al. Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice. Proc. Natl. Acad. Sci. U.S.A. 2004;101:2185–2190. Lichtman S.W, Seliger G, Tycko B, Marder K. Apolipoprotein E and functional recovery from brain injury following post acute rehabilitation. Neurology. 2000;55:1536–1539. Lieberman J.A, Dunbar G, Segreti A.C, Girgis R.R, Seoane F, Beaver J.S, et al. A randomized exploratory trial of an α-7 nicotinic receptor

a mouse model of Angelman syndrome. Neurobiol. Dis. 2012;47(2):210–215. Baxter M.G, Lanthorn T.H, Frick K.M, Golski S, Wan R.Q, Olton D.S. D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol. Aging. 1994;15(2):207–213. Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat. Rev. Drug Discov. 2009;8(3):235–253. Benneyworth M.A, Li Y, Basu A.C, Bolshakov V.Y, Coyle J.T. Cell selective conditional null mutations of serine racemase

demonstrate a predominate localization in cortical glutamatergic neurons. Cell. Mol. Neurobiol. 2012;32(4):613–624. Berrout L, Isokawa M. Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Neurosci. Lett. 2012;516(2):280–284. Bisaz R, Schachner M, Sandi C. Causal evidence for the involvement of the neural cell adhesion molecule, NCAM, in chronic stress-induced cognitive impairments. Hippocampus. 2011;21(1):56–71. Bliss T.V, Collingridge G.L. A synaptic

serving as a marker for neuronal activity (Kubik et al., 2007; Reijmers et al., 2007). Thus, tTA is expressed in cells that were recently active following a specific task. The cFos-tTA mice were injected with a virus encoding for ChR2, driven by tetracycline responsive element (TRE) into their DG. Accordingly, in the injected mice activity drives the expression of tTA in the cells that participate in a specific engram, which subsequently induces the expression of ChR2. This expression is

Download sample

Download

About admin